Challenges for smart people only

Below is a pyramid, in the boxes there will be different numbers such as: 198, 263, 431, 265, 446, 679, 681, 1110. However, there are 2 boxes with the letters E and D.

Your task is to use your intelligence to find the value of the two squares E and D accurately and in accordance with the rules of the number squares.

Finding the answer is not easy at all, hidden in the number boxes are extremely complex hidden rules. Think carefully, find the rules of the number boxes above and choose the appropriate numbers. Hint, the value of E and D consists of 4 digits and is less than 2,500.

Hints have been given, please use your skills and intelligence to find the correct answer.