New technology helps deliver drugs precisely to cancer cells

An international research team led by scientists from the CEITEC Center at Masaryk University (Czech Republic) has just announced a discovery that promises to bring major advances in cancer treatment.

The research team has developed new molecular entities that help deliver drugs precisely to cancer cells, thereby improving treatment effectiveness.

The work has created “supramolecular nanowires” – extremely small, invisible molecular structures that can transport drugs directly into cancer cells. The idea comes from the body’s natural transport mechanism.

Unlike traditional chemotherapy, which destroys both cancer cells and healthy cells, the new technique directly delivers the highly toxic metal palladium into target cells, helping to minimize side effects.

These nanostructures form through a process of “self-assembly,” where individual components spontaneously assemble into a stable mass. Simply dissolve the molecular “building blocks,” heat gently, and after about an hour, they self-assemble into complete nano-rings.

“The biggest challenge was figuring out exactly how the building blocks were put together,” says PhD student Subhasis Chattopadhyay. “We had to combine multiple analytical methods and computational chemistry modeling until the model matched the in vitro product perfectly. It was a long, laborious detective process.”

Biological tests showed that this structure increased the amount of palladium entering cancer cells by nearly 60 times, causing them to shrink and halving their survival rate. Meanwhile, the same dose of palladium without the “nano cage” had almost no significant effect.

Scientists believe that if applied clinically, this method could open up a more effective cancer treatment direction, with more precise targeting and less damage to healthy tissue, helping patients suffer fewer side effects and recover faster.

In addition, this technology can also inspire many new treatments in other medical fields./.

Source: https://www.vietnamplus.vn/cong-nghe-moi-giup-dua-thuoc-nham-chinh-xac-vao-te-bao-ung-thu-post1055823.vnp