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Using genetically modified virus to treat cancer, tumors shrink after 28 days

After 2 months of being injected with the genetically modified virus, the cancerous tumor lesions of two patients disappeared; the tumors of the other two people shrank after 28 days.

Báo Tuổi TrẻBáo Tuổi Trẻ19/07/2025

ung thư - Ảnh 1.

New Chinese treatment opens up much hope for cancer patients - Illustration: REUTERS

According to SCMP , Chinese scientists announced that they have found a way to create cancer-fighting immune cells in the human body using gene editing technology, helping to shorten treatment time and cut costs by more than 80% compared to traditional therapy.

The new therapy is a variation of CAR-T, a cutting-edge immunotherapy currently used to treat blood cancers, asthma and some autoimmune diseases.

Traditional CAR-T requires taking T cells from a patient’s body, growing and genetically modifying them in a lab, and then infusing them back into the body. The process is both expensive and lengthy, with costs that can exceed 1 million yuan (about $139,000) for a single treatment in China.

In a new study published in The Lancet , a team of experts at the Union Hospital of Tongji Medical University (Wuhan) used a genetically modified virus to inject directly into the patient's body. This virus will find T cells and program them to attack cancer cells without the need for intervention outside the body.

The research team affirmed: "This is a ready-to-use product, no longer a drug that is individually formulated for each individual."

In a phase 1 trial, the team treated four patients with multiple myeloma — the second most common blood cancer — with a single injection. The treatment took just 72 hours, rather than the 3-6 weeks required with traditional CAR-T therapy.

After two months of follow-up, two patients achieved strict complete remission (tumor lesions disappeared), and the remaining two achieved partial remission (tumor shrinkage after 28 days).

A Chinese social media platform specializing in cell therapy called it a “milestone” in the field, and said that if tested on a larger scale, the technology could completely change the current “custom medicine” model.

Previously, in June, Capstan Therapeutics (USA) also announced the successful testing of a gene delivery system to create CAR-T in vivo on mice, with positive tumor control results. However, China is the first country to apply this technique on humans.

Scientists consider this a breakthrough, opening up great prospects in popularizing immunotherapy to more patients, not only in the treatment of cancer but also chronic diseases such as asthma and autoimmune diseases.

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Source: https://tuoitre.vn/dung-vi-rut-bien-doi-gene-tri-ung-thu-khoi-u-nho-lai-sau-28-ngay-20250719155921947.htm


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