Scientists at Fudan University in Shanghai, China have identified plasma proteins that play an important role in predicting the risk of dementia about 15 years before detection, with an accuracy of more than 90%.
The team studied 52,645 adults without dementia for an average of more than 14 years. By analyzing data from 1,463 plasma proteins, the researchers found that biomarkers such as glial fibrillary tangle protein (GFAP), NEFL, GDF15, and LTBP2 were associated with all-cause dementia (ACD), Alzheimer's disease (AD), and vascular dementia (or vascular dementia - which occurs when the brain is damaged due to a lack of blood supply).
According to the study, people with higher levels of GFAP were 2.32 times more likely to develop dementia than those with normal levels of GFAP. Notably, GFAP and LTBP2 were highly specific in predicting the likelihood of developing dementia. Meanwhile, GFAP and NEFL proteins typically begin to change 15 years before a person is diagnosed with dementia.
LAM DIEN
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